| 劉清娥 白菊娥 朱明琴 山西省大同市第四人民醫院(大同，037008，中國）
Clinical therapeutic effects of carvedilol on cardiac function in patients with chronic heart failure
LIU Qinge,BAI Jue,ZHU Mingqin.Cardiovascular medicine of DaTong City 4th hospital(Datong,037008,China)
Abstract Objective To observe the effect of carvedilol on left ventricular function.Methods 120 patients with chronic heart failure were randomly divided into two groups. The patients of control experiment group (n=48)were treated with standard care drug treatment (diuretic, digoxin and angiotensin-converting enzyme inhibitor). The patients of carvediol group(n=72) were treated with carvedilol (2.5 mg, twice a day, after two week, their dosages were increased)on the basis of convetional therapy of CHF. Heart rate(HR), left ventricular posterior wall thickness(LVPWT) , the intraventricular septum thickness(IVST), Left ventricular end diastolic diameter(LVEDD), Left ventricular end systolic diameter(LVESD), Left ventricular ejection fraction (LVEF), were measured before and after 6 months treatment respectively.Results Compared with control group, the levels of HR, and LVP and LVS and LVEDD and LVESD decreased after 6 months(P<0.05), LVEF increased in therapeutical group (P<0.05).Conclusion On the basis of conventional therapy of CHF, addition of even smaller dose of carvedilol could improve cardiac function in patients with chronic heart failure and has beneficial effect on left ventricular remodeling.
Keywords chronic heart failure; carvedilol
摘要 目的 探討卡維地洛對慢性心力衰竭（CHF）患者的臨床療效。 方法：將120例CHF患者隨機分爲卡維地洛組和對照組。對照組應用血管緊張素轉換酶抑制劑、利尿劑、洋地黃製劑和（或）硝酸酯類藥物，卡維地洛組在此基礎上加用卡維地洛。分別檢測兩組患者治療前後心率（HR）、左室後壁厚度（LVP）、室間隔厚度（IVS）、左室舒張末期內徑（LVEDD）、左室收縮末期內徑（LVESD）、及左室射血分數（LVEF）。結果：卡維地洛組和對照組相比，HR明顯减慢，LVP、LVS厚度明顯减小，LVEDD、LVESD明顯减小，LVEF明顯增加。結論：卡維地洛治療慢性重症心力衰竭6個月後，具有逆轉左室重構和改善心功能的作用。
關鍵詞 卡維地洛 慢性心力衰竭
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