【作者簡介】王石，女。1978年5月3日生。江蘇鎮江人。2004年畢業于南京中醫藥大學第一臨床醫學院。2004年獲南京中醫藥大學第一臨床醫學院碩士學位。現工作于江蘇省中醫院心內科，職務主治醫師。從事中西醫結合治療心血管病的臨床與科研工作。發表論文2篇，主要有《不穩定心絞痛中醫藥治療近况薈萃》等。擅長解决心力衰竭的中西醫結合治療。亟待開發的科技項目有“中藥顆粒劑治療舒張性心力衰竭”。⒂ 電子郵箱
suewang04@yahoo.com.cn，手機號：13788935246。
摘要 目的 評價注射用丹參多酚酸鹽治療冠心病穩定型心絞痛的有效性和安全性。方法 采用隨機，單盲，陽性藥對照臨床試驗，共觀察受試者45例，其中試驗組30例，對照組15例。分別應用注射用丹參多酚酸鹽200mg，丹參注射液30ml每日1次靜滴，療程10天。對藥物有效性和安全性指標及不良事件進行了觀察。結果 心絞痛療效比較，總有效率試驗組爲90.0％，對照組爲53.3％（P<0.01）。硝酸甘油减停率試驗組爲73.3％，對照組爲53.3%（P<0.05）。心電圖有效率試驗組爲43.3%，對照組爲6.7%（P<0.05）。試驗組不良反應發生率爲6.7%，對照組爲0.0%（P=0.55）。結論 注射用丹參多酚酸鹽治療冠心病穩定型心絞痛患者安全有效。
關鍵詞 丹參多酚酸鹽 丹參注射液 注射劑 冠心病 穩定型心絞痛 臨床試驗
Clinical observation on salvianolate for the treatment of steady angina pectoris in coronary heart disease on 30 patients
WANG Shi,LIU Chunling,LIU Jian,JIANG Weimin,CHEN Xiaohu.The first affiliated hospital of Nanjing university of TCM(Nanjing,210029,China)
Abstract Objective It is to evaluate the clinical curative effect and safety of salvianolate injection for the treatment of steady angina pectoris in coronary heart disease (CHD). Methods A randomized single-blind clinical trials with positive control and 2 parallel tests was carried out in 45 cases. The patients were divided into 2 groups: the control group received salviane injection 30 mL (n=15), the treatment group received salvianolate injection in a dosage of 200 mg once every day. After 10-day treatment, the clinical efficacy and safety were evaluated. Results The total angina pectoris efficacy rates were 90.0% in treatment group, 53.3% in control group (P<0.01); the reductive or stopping using nitroglycerol rates were 73.3% in treatment group , 53.3% in control group (P<0.05); the total ECG efficacy rates were 43.3%in treatment group, 6.7% in control group (P<0.05); adverse reaction rates were 6.7% in treatment group, 0.0% in control group (P=0.55). Conclusion Injective salvianolate is effective and safe for the treatment of CHD steady angina pectoris.
Keywords Salvianolate;Salviane injection;Injection;Coronary heart disease;Steady angina pectoris;Clinical trial
