陈兵阳 综述 曾朝荣 审较
（成都市第七人民医院 成都 610021）
[摘要]血压（BP）不仅受大量外部因素影响，也受诸多内在因素调节，因此存在可预测的变化特征，24hBP节律模式的某些特征与靶组织损害和心脑血管事件触发相关，近年对如何根据BP节律模式治疗高血压（EH）产生了兴趣，本文拟就有关问题作一简要综述。
关键词：高血压；血压节律模式；时间治疗学
Chronotherapy of hypertension. Chen Bingyang , Zeng Chaorong. Department of Cardiology , Chendu Seventh People’s Hospital. Chendu 610041,China
[Abstract] Blood pressure(BP) is affected by a variety of external factors, in addition， is regulated by internal factors, and is characterized by predictable changes over 24 hours. Some specific features of 24h circadian pattern of BP are linked to the progressive injury of target tissues and the triggering of cardiac and cerebrovascular events, there is growing interest in how to tailor the treatment of hypertensive patients according to their circadian BP pattern. This article reviewed related question for BP chrontherapy.
[Key words] Hypertension; Circadian pattern of blood pressure; Chronotherapy
血壓（BP）不僅受大量外部因素影響，也受諸多內在因素如自主神經張力、血管活性激素等的調節，因此BP存在可預測的24hBP變化特徵，這些特徵多與休息/活動周期同步，24hBP節律模式的某些特徵與靶組織損害和心腦血管事件觸發相關。數十年來處理高血壓（EH）時完全低估了內部生物節律對疾病過程的影響及潜在的臨床意義，近年來對如何根據BP節律模式治療EH（即EH時間治療學）産生了興趣。
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